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Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum
Journal: Journal of neurology, neurosurgery, and psychiatry
doi: 10.1136/jnnp-2017-316799
Figure Legend Snippet: Correlation between longitudinal changes in corticospinal tract diffusion measures and changes in ALS Functional Rating Scale (mixed model 29 )
Techniques Used: Diffusion-based Assay, Functional Assay
Related Articles
Diffusion-based Assay:Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum Article Snippet: ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS Functional Rating Scale; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, Frontal Behavioural Inventory; L, left; MD, mean diffusivity; n.s, not signi cant; R, right; UNC, uncinate fasciculus. .. Correlations between DTI measures, ALS disease stage, and clinical scores in 28 C9+ subjects, observations from all visits The within-subject correlation analysis for the 11 C9+ ALS and ALS-FTD subjects showed that the correlation between changes in clinical measures and changes in whole-tract measures of the CST was significant, indicating that a decline in the ALSFRS-R score was moderately correlated with reduced CST FA and increased CST MD ( , ). table ft1 table-wrap mode="anchored" t5 Table 4. Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum Article Snippet: ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS Functional Rating Scale; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, Frontal Behavioural Inventory; L, left; MD, mean diffusivity; n.s, not signi cant; R, right; UNC, uncinate fasciculus. .. Correlations between DTI measures, ALS disease stage, and clinical scores in 28 C9+ subjects, observations from all visits The within-subject correlation analysis for the 11 C9+ ALS and ALS-FTD subjects showed that the correlation between changes in clinical measures and changes in whole-tract measures of the CST was significant, indicating that a decline in the ALSFRS-R score was moderately correlated with reduced CST FA and increased CST MD ( , ). table ft1 table-wrap mode="anchored" t5 Table 4. Functional Assay:Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum Article Snippet: ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS Functional Rating Scale; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, Frontal Behavioural Inventory; L, left; MD, mean diffusivity; n.s, not signi cant; R, right; UNC, uncinate fasciculus. .. Correlations between DTI measures, ALS disease stage, and clinical scores in 28 C9+ subjects, observations from all visits The within-subject correlation analysis for the 11 C9+ ALS and ALS-FTD subjects showed that the correlation between changes in clinical measures and changes in whole-tract measures of the CST was significant, indicating that a decline in the ALSFRS-R score was moderately correlated with reduced CST FA and increased CST MD ( , ). table ft1 table-wrap mode="anchored" t5 Table 4. Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum Article Snippet: ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS Functional Rating Scale; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, Frontal Behavioural Inventory; L, left; MD, mean diffusivity; n.s, not signi cant; R, right; UNC, uncinate fasciculus. .. Correlations between DTI measures, ALS disease stage, and clinical scores in 28 C9+ subjects, observations from all visits The within-subject correlation analysis for the 11 C9+ ALS and ALS-FTD subjects showed that the correlation between changes in clinical measures and changes in whole-tract measures of the CST was significant, indicating that a decline in the ALSFRS-R score was moderately correlated with reduced CST FA and increased CST MD ( , ). table ft1 table-wrap mode="anchored" t5 Table 4. Imaging:Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum Article Snippet: ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS Functional Rating Scale; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, Frontal Behavioural Inventory; L, left; MD, mean diffusivity; n.s, not signi cant; R, right; UNC, uncinate fasciculus. .. Correlations between DTI measures, ALS disease stage, and clinical scores in 28 C9+ subjects, observations from all visits The within-subject correlation analysis for the 11 C9+ ALS and ALS-FTD subjects showed that the correlation between changes in clinical measures and changes in whole-tract measures of the CST was significant, indicating that a decline in the ALSFRS-R score was moderately correlated with reduced CST FA and increased CST MD ( , ). table ft1 table-wrap mode="anchored" t5 Table 4. Modification:Article Title: Longitudinal diffusion imaging across the C9orf72 clinical spectrum Article Snippet: ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised ALS Functional Rating Scale; CCg, corpus callosum—genu; CCm, corpus callosum—motor; CCpm, corpus callosum—pre-motor; CCsp, corpus callosum—splenium; CST, corticospinal tract; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, Frontal Behavioural Inventory; L, left; MD, mean diffusivity; n.s, not signi cant; R, right; UNC, uncinate fasciculus. .. Correlations between DTI measures, ALS disease stage, and clinical scores in 28 C9+ subjects, observations from all visits The within-subject correlation analysis for the 11 C9+ ALS and ALS-FTD subjects showed that the correlation between changes in clinical measures and changes in whole-tract measures of the CST was significant, indicating that a decline in the ALSFRS-R score was moderately correlated with reduced CST FA and increased CST MD ( , ). table ft1 table-wrap mode="anchored" t5 Table 4. |